Killer Differentials

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Poor R Wave Progression DDx

Key Points Poor R Wave Progression (PRWP): This refers to a situation where the R waves in the precordial leads (V1 to V6) fail to increase in amplitude as expected….

Long QT Interval DDx

Key Points The QT interval is the time from the start of the Q wave to the end of the T wave. It represents the total time for ventricular depolarization…

Large T Wave DDx

Key Points Large T waves on an ECG can have several different etiologies, ranging from benign to life-threatening conditions. It’s essential to interpret them in the clinical context and with…

ST Elevation in aVR DDx

Key Points Global Subendocardial Ischemia: ST-segment elevation in aVR with diffuse ST-segment depression in multiple other leads typically reflects global subendocardial ischemia of the left ventricle. Proximal Vessel Occlusion: This…

T Wave Inversion in V1-V3 DDx

Key Point Misconceptions: T wave inversions (TWIs) in V1-V3 are often assumed to indicate anteroseptal ischemia, but there are multiple other causes to consider. The following is a list of…

Syncope DDx

Key Points Syncope and the ECG: Syncope is a transient loss of consciousness and postural tone, characterized by rapid onset, brief duration, and spontaneous recovery without medical intervention. Cardiac syncope…

Short QT Interval DDx

Key Points Short QT Interval: A QT interval is considered short when the corrected QT (QTc) interval is less than 350 ms. A short QT interval on the ECG can…

Right Axis Deviation + STE DDx

Key Points RAD + ST-Segment Elevation: When you encounter right axis deviation (RAD) combined with ST-segment elevation (STE) on an ECG, it’s crucial to consider differential diagnoses beyond STEMI, as…

Left Axis Deviation DDx

Key Points Definition: Left Axis Deviation (LAD) occurs when the QRS axis on an ECG is shifted leftward, typically between -30° and -90°. Common Causes: LAD is often associated with…

Right Axis Deviation DDx

Top 3 emergent causes of new rightward axis to consider: When encountering a new rightward axis on an ECG, immediately consider the following life-threatening conditions: Acute Right Heart Strain /…

Not Enough P Waves (P:QRS < 1) DDx

Key Points Not Enough P’s: When the ratio of P waves to QRS complexes is less than 1, this suggests the presence of ectopic beats, escape rhythms, or abnormal conduction….

No clear P waves DDx

Key Points Absence of Sinus Rhythm: The lack of clear P waves before the QRS complexes suggests that sinus rhythm is not present. Potential Causes: This pattern can result from…

Narrow QRS Bradycardia DDx

Key Point Narrow QRS Bradycardias: These rhythms are more commonly associated with vagal stimulation or reversible causes, making them generally less severe than wide QRS bradycardias. Due to their better…

Tall R wave in V1 DDx

Key Points R Wave Represents Depolarization: The R wave in V1 reflects the initial depolarization of the ventricles, specifically the right ventricle. Height Relative to S Wave: In V1, the…

Narrow & Irregular Tachycardia DDx

Key Points Narrow Complex Tachycardia: Refers to a tachycardia with a QRS duration of less than 120 ms and an irregular rhythm. The primary rhythms to consider in this scenario…

Non-Conducted P Waves (P:QRS>1) DDx

Key Point ECG Interpretation Caution: The ECG computer interpretation is often unreliable, especially when irregular rhythms or non-conducted P waves are present. It frequently misinterprets irregular rhythms as atrial fibrillation….

Narrow & Regular Tachycardia DDx

Key Points Narrow Complex Tachycardia: Refers to a tachycardia with a QRS duration of less than 120 ms and a regular rhythm. The primary rhythms to consider in this scenario…

Acute Chest Pain DDx

Key Point When evaluating a patient with acute chest pain, it is crucial to consider rapidly fatal conditions and use a systematic approach to ECG interpretation to assess the probability…

Low Voltage QRS DDx

Key Points Definition: Low voltage QRS is characterized by a QRS amplitude of less than 5 mm in limb leads and less than 10 mm in precordial leads. Sensitive Definition…

ST Elevation DDx

Key Points Definition: ST elevation on an ECG refers to the upward displacement of the ST segment above the baseline, often indicating acute myocardial injury. Significance: While ST elevation is…

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