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Key Points

  • ECG as a Critical Diagnostic Tool: In toxicology, the ECG is often the first and most reliable clue. Early recognition of drug-induced conduction disturbances or arrhythmias can guide life-saving interventions.
  • 6 high‑yield tox causes of dangerous ECG changes to keep top of mind:
    1. Sodium channel blockers: wide QRS, terminal R in aVR, seizures or VT risk.
    2. Beta‑blockers and calcium channel blockers: bradycardia plus hypotension, AV block.
    3. Digoxin: atrial tachycardia with block, scooped ST segments, bidirectional VT.
    4. Opioids: respiratory failure first, secondary bradyasystolic events.
    5. Cocaine and other sympathomimetics: tachyarrhythmias, ischemia, occasional wide QRS.
    6. Cannabis: sympathetic surge and pro‑ischemic physiology in some users, arrhythmias and ACS have been reported.
  • Early Recognition Saves Lives: Identifying these ECG changes early allows for prompt intervention, including the use of sodium bicarbonate, which can reverse the cardiotoxic effects and prevent deterioration.

Sodium Channel Blocker Toxicity

  • ECG: QRS widening ≥100 ms is the hallmark. Wider QRS correlates with VT or VF risk. QT may prolong. R in aVR >3 mm supports severe blockade.
  • Treatment: Sodium bicarbonate is first line. Typical approach is 1–2 mEq/kg IV bolus, repeat until QRS narrows and pH is 7.50 to 7.55, then infusion as needed. Optimize potassium and magnesium.
  • Classic example: TCA overdose with wide QRS and dominant R in aVR. Sinus tachycardia is common from anticholinergic effect. QRS >160 ms predicts seizures and VT.

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Beta-Blocker & Calcium Channel Blocker Overdose

  • ECG: Bradycardia, AV block, PR prolongation.
  • Treatment:
    • Beta‑blocker overdose: glucagon bolus, then infusion if responsive.
    • Calcium channel blocker overdose: IV calcium salts.
    • High‑dose insulin euglycemia therapy for refractory shock in either group. Start dextrose and monitor potassium closely. Add vasoactive agents as needed.

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Digoxin Toxicity

  • ECG: Downsloping ST “dig effect” reflects use, not toxicity. Toxicity suggests atrial tachycardia with block, frequent PVCs, AV block, or bidirectional VT. PR often prolongs.
  • Treatment: Digoxin‑specific antibody fragments for unstable patients, life‑threatening dysrhythmias, or significant hyperkalemia. Avoid cardioversion if possible. Prioritize Fab when hyperkalemia is present.

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Opioid Overdose

  • Primary problem: Respiratory depression and hypoxia.
  • ECG: Secondary bradycardia, asystole, or hypoxia‑driven dysrhythmias.
  • Management: Airway first. Naloxone titrated to ventilation. Consider infusion for long‑acting agents. Monitor for co‑ingestants.

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Cocaine & Other Sympathomimetics

  • Mechanism: Adrenergic surge plus sodium channel blockade at high doses.
  • ECG: Sinus tachycardia, ST changes, QT prolongation, possible wide QRS. Risk of MI, stroke, aortic dissection, VT or VF.
  • Treatment: Benzodiazepines for agitation and autonomic control. Nitrates and calcium channel blockers for vasospasm. Avoid pure beta‑blockade. 

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Methamphetamine Toxicity

  • ECG: Sinus tachycardia, ST changes from demand ischemia, QT prolongation.
  • Complications: Hyperthermia, rhabdomyolysis, DIC, cardiomyopathy.
  • Treatment: Aggressive cooling, benzodiazepines, fluids, treat complications early.

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Cannabis (Marijuana) Toxicity

  • ECG and risk: Sinus tachycardia is common. Reports describe QT prolongation, atrial and ventricular arrhythmias, and ACS including MI. Risk can rise shortly after use.
  • Clinical note: Edibles are not benign. Regular use has been associated with endothelial dysfunction. Consider cannabis exposure a risk accelerant in young patients with chest pain.
  • Management: Treat per standard ACS and arrhythmia pathways. Counsel on cardiovascular risk.

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KEY CLINICAL PEARLS:

  • QRS Widening is a Red Flag: In any suspected drug overdose, a widened QRS complex on the ECG should prompt immediate consideration of sodium channel blocker toxicity, and sodium bicarbonate therapy should be initiated.
  • aVR Lead as a Diagnostic Tool: Pay close attention to the aVR lead in cases of sodium channel blocker or TCA overdose. A prominent R wave in aVR is a strong indicator of severe toxicity.
  • Bradycardia and Hypotension: In the context of beta-blocker or calcium channel blocker overdose, bradycardia coupled with hypotension is a critical finding. Early intervention with glucagon, calcium, or high-dose insulin therapy may be required.
  • Digoxin Effect vs. Toxicity: Distinguish between the therapeutic “digoxin effect” on the ECG and signs of toxicity, which may require digoxin-specific antibody therapy.
  • Rapid Action for Reversal: Drug-induced toxicological emergencies require rapid recognition and prompt treatment. Sodium bicarbonate for sodium channel blocker toxicity, glucagon for beta-blocker overdose, and digoxin-specific antibodies for digoxin toxicity can be life-saving.
  • Continuous Monitoring: In all toxicological emergencies, continuous ECG monitoring is essential to detect and respond to life-threatening arrhythmias as they develop.